N. Zaidi

A genetically-encoded nanobody sensor reveals conformational diversity in beta-arrestins orchestrated by distinct seven transmembrane receptors

This study introduces a nanobody sensor to detect conformational changes in beta-arrestins upon GPCR activation, revealing receptor-specific conformational diversity.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

This study presents cryo-EM structures of GPR109A-G-protein complexes with agonists and uses them to engineer biased agonists with reduced flushing effects.

SpliceMutr enables pan-cancer analysis of splicing-derived neoantigen burden in tumors

SpliceMutr quantifies splicing-derived neoantigens across cancers, finding correlations with immune biomarkers and treatment response.

A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

Aging interacts with tumor biology to produce major changes in the immune tumor microenvironment

The paper examines how aging interacts with tumor biology to alter the immune tumor microenvironment, identifying age-specific immune cell changes and immune checkpoint gene expression patterns.

Transfer learning between preclinical models and human tumors identifies conserved NK cell activation signature in anti-CTLA-4 responsive tumors

The paper uses transfer learning to identify a conserved NK cell activation signature in anti-CTLA-4 responsive tumors across preclinical models and humans, showing its clinical relevance.

Abundance, fatty acid composition and saturation index of neutral lipids are significantly different between isogenic primary and metastatic colon cancer cell lines

This study compares lipid composition between primary and metastatic colon cancer cell lines, finding significant differences in triglyceride and cholesterol ester saturation indices.

Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia

The paper examines how cancer cells adjust lipid homeostasis under nutrient-deprivation and hypoxia, finding that lipid class stability is maintained under hypoxia but disrupted under nutrient-deprivation.