Cell BiologybioRxiv
Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilities
R. Aprigliano, S. Bradamante, B. Mihaljevic…·B. Van Loon
This study identifies increased p53 signaling as the cause of impaired neural differentiation in HUWE1-promoted XLIDs, showing that reducing p53 levels rescues neurodevelopmental defects.
DOI 10.1016/j.xcrm.2021.100240