M. Bjoras

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

Active components of commonly prescribed medicines affect influenza A virus-host cell interaction: a pilot study

This study examines how active components of commonly prescribed medicines affect influenza A virus-host cell interactions both in silico and in vitro.

Nafamostat-interferon-alpha combination suppresses SARS-CoV-2 infection by targeting cooperatively host TMPRSS2 in vitro and in vivo

This study combines nafamostat and interferon-alpha to suppress SARS-CoV-2 infection by targeting TMPRSS2 in vitro and in vivo.

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

Identification of novel antiviral drug combinations in vitro and tracking their development

This study identifies novel synergistic antiviral drug combinations effective against SARS-CoV-2, echovirus 1, HCV, and HIV-1 in vitro and provides an online resource for their developmental status.

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV

This study uses PepSeq to map SARS-CoV-2 antibody epitopes and identifies cross-reactivity with hCoV-OC43.

Potential antiviral options against SARS-CoV-2 infection

The paper identifies potent convalescent sera and broad-spectrum antivirals effective against SARS-CoV-2 using a neutralization assay and cell culture screening.

Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilities

This study identifies increased p53 signaling as the cause of impaired neural differentiation in HUWE1-promoted XLIDs, showing that reducing p53 levels rescues neurodevelopmental defects.

Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability

This study shows antibiotic-induced DNA damage in E. coli leads to pH homeostasis loss and genome instability, with environmental pH affecting resistance development and physiological responses.

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

Critical Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

This study identifies critical host-virus interaction nodes through network analysis and drug re-purposing, revealing key targets for antiviral therapies.