Author

T. Laurent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:benchmark study· 1

Frequent Co-Authors

R. Josien· 3 shared A. Bourreille· 2 shared A. Fantou· 2 shared J. C. Martin· 2 shared L.-A. Carlson· 2 shared A. Broquet· 1 shared A. Carlson· 1 shared A. D. Polydorides· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

R. Josien

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

D. Jha, Z. Al-Taie, A. Krek, S. T. Eshghi, A. Fantou, T. Laurent, M. Tankelevich, X. Cao, H. Meringer, A. Livanos, M. Tokuyama, F. Cossarini, A. Bourreille, R. Josien, R. Hou, , S. Mehandru

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

bioRxiv · Jun 2, 2023 · PreprintImmunology

A gene-expression module in circulating immune cells is associated with cell migration during immune diseases.

D. Sinha, T. Laurent, A. Broquet, C. Fourgeux, T. Letellier, G. Tilly, S. Bruneau, S. Ville, L. Bouchet-Delbos, J. Branchereau, C. Kerleau, S. Brouard, G. Blancho, M. Giral, R. Josien, , J. Poschmann

The paper identifies a gene expression module in circulating immune cells linked to migration during immune diseases and shows its role in tissue recruitment and immune activation.

bioRxiv · Apr 11, 2023Immunology

The organization of double-stranded RNA in the chikungunya virus replication organelle

T. Laurent, L.-A. Carlson

This study examines the organization of double-stranded RNA in chikungunya virus spherules using cryo-electron tomograms, revealing structural features of the replication intermediate.

bioRxiv · Dec 19, 2022Microbiology

Architecture of the chikungunya virus replication organelle

T. Laurent, P. Kumar, S. Liese, F. Zare, M. Jonasson, A. Carlson, L.-A. Carlson

This study uses cryo-electron tomography to reveal the architecture of CHIKV spherules and presents a mathematical model explaining their membrane remodeling.

bioRxiv · Apr 5, 2022Biophysics

IL-22BP production is heterogeneously distributed in Crohn's disease

A. Fantou, E. Lagrue, T. Laurent, L. Delbos, S. Blandin, A. Jarry, G. Beriou, C. Braudeau, N. Salabert-Le Guen, E. Marin, A. Moreau, J. Podevin, A. Bourreille, R. Josien, J. C. Martin

This study investigates IL-22BP production and distribution in Crohn's disease tissues, finding higher levels in ileum and associations with eosinophils, moDCs, and smoking.

bioRxiv · Apr 7, 2021Immunology

A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol

K. Kasho, G. Stojkovic, C. Velazquez-Ruiz, M. I. Martinez-Jimenez, T. Laurent, A. E. Perez-Rivera, L. Jenninger, L. Blanco, S. Wanrooij

This study identifies an arginine cluster in PolDIP2 that enhances PrimPol's nucleotide binding and DNA synthesis by increasing its primer-template and dNTP affinity.

bioRxiv · May 18, 2020Biochemistry