D. Sinha

Low-Cost Robotic Manipulation of Live Microtissues for Cancer Drug Testing

This paper presents a low-cost robotic platform for manipulating live microtissues to enable cancer drug testing using patient biopsies on 384-well plates.

The mechanosensitive Pkd2 channel modulates the recruitment of myosin II and actin to the cytokinetic contractile ring

This study shows that the Pkd2 channel regulates myosin II and actin recruitment to the cytokinetic contractile ring in fission yeast, suggesting a calcium-dependent mechanism.

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance.

This paper identifies five CiaR-controlled Ccn sRNAs in S. pneumoniae that modulate Zn resistance and virulence by regulating metal homeostasis and detoxification mechanisms.

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

A gene-expression module in circulating immune cells is associated with cell migration during immune diseases.

The paper identifies a gene expression module in circulating immune cells linked to migration during immune diseases and shows its role in tissue recruitment and immune activation.

Non-canonically regulated heterochronic expression of Hsp70 drives clonal expansion and invasion in Drosophila epithelial tumors

This study shows that non-canonical Hsp70 regulation via ROS-JNK-FOXO pathway drives clonal expansion and invasion in Drosophila epithelial tumors.

Cytoplasmic tail of the putative polycystin channel Pkd2 regulates its clustering in the fission yeast eisosomes

The paper investigates how the cytoplasmic tail of Pkd2 regulates its clustering in fission yeast eisosomes, showing that both plasma membrane microdomains and the cytoplasmic tail are involved.

Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy

This study investigates the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy and finds that cytoplasmic MMC is not a sensor for volume regulation, while membrane tension is critical.

Fission yeast polycystin Pkd2p promotes the cell expansion and antagonizes the Hippo pathway SIN

This study identifies Pkd2p in fission yeast as promoting cell expansion during interphase and antagonizing the Hippo pathway SIN during cytokinesis.

Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis

This study investigates the roles of RNase Y and PNPase in Streptococcus pneumoniae virulence and transcriptome regulation, showing their distinct impacts on gene expression and pathogenesis.

Delineating the complex mechanistic interplay between autophagy and monocyte to macrophage differentiation: a functional perspective

This study investigates the role of autophagy in monocyte to macrophage differentiation, showing its critical role in sustaining the process and directing differentiation via protein degradation.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

This study shows that Cep55 regulates PI3K/Akt signaling, essential for neocortical development and ciliogenesis, using mouse models and human organoids.

S1-Domain RNA-Binding Protein (CvfD) Is a New Post-Transcriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in Streptococcus pneumoniae D39

This paper identifies CvfD, an S1-domain RNA-binding protein in Streptococcus pneumoniae, showing it regulates cold sensitivity, phosphate transport, and virulence through post-transcriptional mechanisms.

NBS1-CtIP-Mediated DNA End Resection Regulates cGAS Binding to Micronuclei

The paper shows NBS1-CtIP-mediated DNA end resection prevents cGAS from binding to micronuclei by modifying chromatin architecture.

Rapid, direct detection of bacterial Topoisomerase 1 - DNA adducts by RADAR/ELISA

This paper develops a rapid assay to detect bacterial Topoisomerase 1-DNA adducts using RADAR fractionation and ELISA, showing it is as effective as traditional methods.

Differential tissue stiffness of body column facilitates locomotion of Hydra on solid substrates

This study shows that differential tissue stiffness in Hydra's body column enables somersaulting locomotion on solid substrates, supported by mechanical measurements and computational models.

TUTase mediated site-directed access to clickable chromatin employing CRISPR-dCas9

This paper develops sgRNA-Click (sgR-CLK), a method to site-directly display synthetic molecules on chromatin using CRISPR-dCas9 and bioorthogonal click chemistry.

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

Cep55 overexpression promotes genomic instability and tumorigenesis in mice

This study shows that Cep55 overexpression causes genomic instability and tumorigenesis in mice by promoting mitotic errors and disrupting DNA repair mechanisms.

Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis

This study identifies Pkd2p, a TRP channel in fission yeast, as a regulator of cytokinesis by modulating osmotic homeostasis and cell separation.