Cell BiologybioRxiv
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
D. Zawada, J. Kornherr, A. B. Meier…·A. Goedel
This study shows that modulating retinoic acid signaling in human pluripotent stem cells generates heart field-specific progenitors, including a novel juxta-cardiac field, and identifies transcriptional dysregulation in a patient with hypoplastic left heart syndrome.