Author

D. Ortmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

L. Vallier· 3 shared A. Osnato· 2 shared S. Brown· 2 shared A. B. Meier· 1 shared A. Goedel· 1 shared A. J. Collier· 1 shared A. Moretti· 1 shared A. Ross· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

L. Vallier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

D. Zawada, J. Kornherr, A. B. Meier, G. Santamaria, T. Dorn, D. Ortmann, M. Lachmann, M. Ortiz, S. C. Harmer, M. Nobles, A. Tinker, R. A. Pedersen, P. Grote, K.-L. Laugwitz, A. Moretti, A. Goedel

This study shows that modulating retinoic acid signaling in human pluripotent stem cells generates heart field-specific progenitors, including a novel juxta-cardiac field, and identifies transcriptional dysregulation in a patient with hypoplastic left heart syndrome.

bioRxiv · May 30, 2022Cell Biology

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

A. Osnato, S. Brown, C. Krueger, S. Andrews, A. J. Collier, S. Nakanoh, M. Quiroga Londono, B. T. Wesley, D. Muraro, S. Brumm, K. Niakan, L. Vallier, D. Ortmann, P. J. Rugg-Gunn

This study shows that TGFβ signalling maintains naive human pluripotency by regulating SMAD2/3 binding and gene expression, with distinct effects compared to primed hPSCs.

bioRxiv · Jul 10, 2021Cell Biology

Epigenetic regulations follow cell cycle progression during differentiation of human pluripotent stem cells.

P. Madrigal, S. Pauklin, K. Jee Goh, R. Grandy, A. Osnato, D. Ortmann, L. Vallier, S. Brown

This study investigates epigenetic changes during the first two cell divisions of human pluripotent stem cell differentiation using synchronized cultures and identifies key regulatory mechanisms.

bioRxiv · Jun 26, 2020Cell Biology

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease

R. Elmentaite, A. Ross, K. R. James, D. Ortmann, T. Gomes, K. Roberts, K. Nayak, L. Tuck, O. Bayraktar, R. Heuschkel, L. Vallier, S. A. Teichmann, M. Zilbauer

The paper maps the developing human gut at 6-10 weeks post-conception using single-cell sequencing and links fetal transcriptional patterns to childhood Crohn's disease.

bioRxiv · Feb 6, 2020Cell Biology