Author

A. Tinker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Nobles· 2 shared A. B. Meier· 1 shared A. Goedel· 1 shared A. Kowala· 1 shared A. Moretti· 1 shared A. Paredes-Redondo· 1 shared C. M. Webb· 1 shared C. Morera· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

M. Nobles

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

D. Zawada, J. Kornherr, A. B. Meier, G. Santamaria, T. Dorn, D. Ortmann, M. Lachmann, M. Ortiz, S. C. Harmer, M. Nobles, A. Tinker, R. A. Pedersen, P. Grote, K.-L. Laugwitz, A. Moretti, A. Goedel

This study shows that modulating retinoic acid signaling in human pluripotent stem cells generates heart field-specific progenitors, including a novel juxta-cardiac field, and identifies transcriptional dysregulation in a patient with hypoplastic left heart syndrome.

bioRxiv · May 30, 2022Cell Biology

CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model

C. Morera, J. Kim, A. Paredes-Redondo, M. Nobles, D. Rybin, R. Moccia, A. Kowala, J. Meng, S. Garren, P. Liu, J. E. Morgan, F. Muntoni, N. Christoforou, J. Owens, A. Tinker, Y.-Y. Lin

This study uses CRISPR to correct dystrophin mutations in DMD patient-derived PSCs, revealing impaired Ca2+ handling and showing rescue through gene correction.

bioRxiv · Feb 17, 2022Cell Biology

Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy

K.-E. Ng, P. J. Delaney, D. Thenet, S. Murtough, C. M. Webb, E. Tsisanova, S. L. Walker, J. D. Westaby, D. J. Pennington, R. Pink, D. P. Kelsell, A. Tinker

The paper identifies early cardiac inflammation as a key driver in a murine model of arrhythmogenic cardiomyopathy, linking desmoglein 2 loss to inflammatory pathway activation and fibrosis.

bioRxiv · Jun 24, 2020 · PreprintImmunology