Author

S. Chakrapani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Kumar· 2 shared S. Basak· 2 shared A. Kapoor· 1 shared E. Gibbs· 1 shared M. Filizola· 1 shared M. L. Mayer· 1 shared M. Sansom· 1 shared S. Ramsey· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

A. Kumar

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2 papers

Recent·Most cited

High-resolution Structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

S. Basak, A. Kumar, S. Ramsey, E. Gibbs, A. Kapoor, M. Filizola, S. Chakrapani

This study presents high-resolution cryo-EM structures of 5-HT3AR-setron complexes, revealing distinct interaction fingerprints and a novel mechanism of competitive inhibition.

bioRxiv · Mar 30, 2020Biophysics

Mechanisms of activation and desensitization of full-length glycine receptor in membranes

A. kumar, S. Basak, S. Rao, Y. Gicheru, M. L. Mayer, M. Sansom, S. Chakrapani

This study presents Cryo-EM structures of full-length glycine receptors in different functional states, revealing conformational changes and validating their function through molecular dynamics simulations.

bioRxiv · Sep 30, 2019Biophysics