S. Basak

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT

This paper introduces MIET-PAINT, a method combining DNA-PAINT and Metal-Induced Energy Transfer to achieve nanometer-scale 3D imaging with high multiplexing capability.

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

This study uses super-resolution imaging to reveal the dynamic nanoscale architecture of CaV1.3 channel clusters in cardiac myocytes, showing mobile channels within nanodomains rather than dense packing.

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundaries

This paper identifies the alphavirus TF protein's role in promoting viral propagation by altering cell-cell boundaries through downregulation of Scribble.

Fuzzy Supertertiary Interactions within PSD-95 Enable Ligand Binding

This study uses molecular dynamics and FRET to analyze PSD-95's conformational dynamics and shows how its flexible structure enables ligand binding.

A vitamin D-RelB/NF-κB pathway limits Chandipura virus multiplication by rewiring the homeostatic state of autoregulatory type 1 interferon-IRF7 signaling

This study identifies a vitamin D-RelB/NF-κB pathway that limits Chandipura virus multiplication by enhancing type 1 interferon production through IRF7 autoregulation.

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1

This study shows that SERMs inhibit alphavirus infection by targeting the viral capping enzyme nsP1, with antiviral effects observed in cell culture and mice.

Cryo-EM Structure of Bacterioferritin Nanocages Provides Insight into the Bio-mineralization of Ferritins

The paper reports cryo-EM structures of bacterioferritin nanocages and identifies residues involved in iron transport and biomineralization.

Overexpression of EiKCS confers paraquat-tolerance in rice (Oryza sativa L.) by promoting polyamine pathway

Overexpressing EiKCS from goosegrass in rice increases polyamine levels and enhances paraquat tolerance through improved antioxidant capacity and photosynthesis.

An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module

The paper shows that noncanonical NF-κB signaling in intestinal epithelial cells enhances latent RelA dimers, amplifying canonical NF-κB activity and exacerbating intestinal inflammation in IBD.

High-resolution Structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

This study presents high-resolution cryo-EM structures of 5-HT3AR-setron complexes, revealing distinct interaction fingerprints and a novel mechanism of competitive inhibition.

Mechanisms of activation and desensitization of full-length glycine receptor in membranes

This study presents Cryo-EM structures of full-length glycine receptors in different functional states, revealing conformational changes and validating their function through molecular dynamics simulations.

Chandipura virus requires pro-survival RelA NF-κB function for its propagation

This study shows that RelA NF-κB promotes Chandipura virus growth by preventing cell death, contrary to its typical anti-viral role.