A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid
Q. Shen, C. Xu, S. Jang, Q. Xiong, S. Devarkar, T. Tian, G. Bedwell, T. Tripler, Y. Hu, S. Yuan, J. Temple, J. Shi, C. Aiken, A. Engelman, J. R. Perilla, , Y. Xiong
This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.
bioRxiv · Aug 10, 2020 · PreprintMicrobiology