C. P. Lusk

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope

This study quantifies the timeline of nuclear autophagy in yeast, revealing a role for Dnm1 in nuclear envelope remodeling during cargo removal.

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity

The paper investigates ESCRT-III proteins' roles in maintaining nuclear envelope integrity during mitosis and interphase, revealing distinct functions of CHMP7/Cmp7 and a diffusion barrier.

Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome

This study identifies Atg39 as a cargo adaptor that targets inner nuclear membrane components for autophagy by forming lumenal vesicles in the nuclear envelope.

A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state

The paper shows Heh2/Man1 interacts with NPC components in yeast and suggests it senses NPC assembly state for quality control and segregation.

Direct PA-binding by Chm7 is required for nuclear envelope surveillance at herniations

The paper identifies PA-binding by Chm7 as essential for nuclear envelope surveillance at herniations in budding yeast.

A physicochemical roadmap of yeast replicative aging

This study measures physicochemical changes in yeast cells during replicative aging, finding acidification and organellar crowding contribute to homeostatic decline.

Torsin ATPases are required to complete nuclear pore complex biogenesis in interphase

The paper identifies MLF2 as a component of nuclear envelope blebs and shows that Torsin ATPases are essential for completing nuclear pore complex biogenesis in interphase.

Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication

This study identifies Nup188 as a functional component of pericentriolar material, showing its distinct turnover and role in centriole duplication, which may contribute to congenital heart disease.

Quantification of biomolecular dynamics inside real and synthetic nuclear pore complexes using time-resolved atomic force microscopy

The paper uses AFM to study biomolecular dynamics in real and synthetic nuclear pore complexes, revealing slow collective transitions in mimetic NPCs due to FG-nup interactions.

An ESCRT-LEM domain inner nuclear membrane protein surveillance system is poised to directly monitor the integrity of the nuclear envelope barrier and nuclear transport system

The paper identifies a surveillance system in yeast that detects and seals nuclear envelope damage through ESCRT and inner nuclear membrane proteins.

Expression of TorsinA in a heterologous yeast system reveals interactions with conserved lumenal domains of LINC and nuclear pore complexes

This study expresses TorsinA in yeast to investigate its interactions with nuclear envelope components, revealing specific roles for TorsinA and its mutant in nuclear pore complex interactions.