Q. Shen

Interspecies interaction reshapes the fitness landscape of evolved genotypes

This study investigates how interspecies interactions shape genetic and phenotypic diversity in a two-species microbial consortium over evolutionary time.

Bridging the Gap: biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia

This study investigates bacterial-fungal interactions between Bacillus velezensis and Trichoderma guizhouense, showing biofilm-mediated colonization and gene expression changes that reveal complex dynamics in soil microbiota.

Channel width modulates the permeability of DNA origami based nuclear pore mimics

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Optimization of an adeno-associated viral vector for epidermal keratinocytes in vitro and in vivo

This study optimizes an AAV vector for efficient gene delivery to epidermal keratinocytes in vitro and in vivo by engineering capsid and promoter components.

Mechanically Sheared Axially Swept Light-Sheet Microscopy

The paper introduces a new image acquisition method for light-sheet microscopes that improves spatial context placement and reduces post-processing needs, achieving higher field of view and resolution.

navigate: an open-source platform for smart light-sheet microscopy.

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

Cebranopadol, a novel long-acting opioid agonist with low abuse liability, to treat opioid use disorder: Preclinical evidence of efficacy

This study evaluates cebranopadol's efficacy and abuse liability in treating opioid use disorder using rat models, showing reduced self-administration and stress-induced reinstatement compared to heroin.

Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

This study shows that warming and altered precipitation independently and together reduce alpine soil microbial growth by 40-90%, with some taxa showing increased growth under specific climate conditions.

A novel mitochondrial regulon for Ferroptosis during fungal pathogenesis

This study identifies a mitochondrial regulon essential for ferroptosis in the fungal pathogen Magnaporthe oryzae, linking mitochondrial metabolism and redox regulation to fungal pathogenesis.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

Liproxstatin-1 alleviates cartilage degradation by inhibiting chondrocyte ferroptosis in temporomandibular joint

This study shows that ferroptosis contributes to TMJOA cartilage degradation and that Lip-1 inhibits this process by reducing ferroptosis markers and oxidative stress in chondrocytes.

ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

In vivo reprogramming of wound-resident cells generates skin with hair

This study reprograms wound-resident cells in adult mice to generate skin with hair follicles, demonstrating de novo appendage formation.

Bacillus velezensis SQR9 sways the rhizosphere community and its sociality toward cooperation and plant growth promotion

This study shows that B. velezensis SQR9 alters rhizosphere microbial community structure and promotes cooperation among Bacillus species, enhancing plant growth.

ZEB2 regulates the development of CD11c+ atypical B cells

The paper identifies ZEB2 as a key transcription factor regulating the development of CD11c+ atypical B cells in both mice and humans.

A toxin-mediated policing system in Bacillus improves population fitness via penalizing non-cooperating phenotypic cheaters

This study identifies a toxin-mediated policing system in Bacillus that punishes phenotypic cheaters, enhancing population fitness in plant rhizosphere and under stress.

Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammals

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

CLASP2 stabilizes GDP-associated terminal tubulins to prevent microtubule catastrophe

This study identifies CLASP2's mechanism of stabilizing GDP-associated terminal tubulins to prevent microtubule catastrophe.

Housekeeping gene gyrA, a potential molecular marker for Bacillus ecology study

This study evaluates the use of the housekeeping gene gyrA as a molecular marker for Bacillus species diversity and ecology, showing improved resolution compared to 16S rRNA.

Engineering ecologically complementary rhizosphere probiotics using consortia of specialized bacterial mutants

This study improves plant growth-promotion by engineering specialized bacterial mutants within a single species and assembling them into consortia that enhance root colonization and disease resistance.

A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

Keystone species determine the productivity of synthetic microbial biofilm communities

The paper identifies keystone species in synthetic microbial biofilm communities that influence their productivity through metabolic facilitation or competition.

Fungal auxin is a quorum-based modulator of blast disease severity

This study identifies fungal auxin as a quorum-sensing signal modulating rice blast disease severity through IAA biosynthesis and secretion.

Annulment of antagonism shifts properties that are beneficial to plants in two-member consortia of Bacillus velezensis

This study shows that modifying the Spo0A gene in B. velezensis SQR9 improves plant growth promotion when combined with FZB42 in two-member consortia.

A unique genomic island-governed cannibalism in Bacillus enhanced biofilm formation through a novel regulation mechanism

This study identifies a novel cannibalism mechanism in Bacillus velezensis SQR9 mediated by bacillunoic acids, enhancing biofilm formation and interspecies competition through a two-component regulatory system.

Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus

The paper investigates the relationship between antagonism and phylogeny in Bacillus by analyzing biosynthetic gene clusters (BGCs) and finds a positive correlation between BGC distance and phylogenetic distance.