Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion
Y. Sun, T. J. Florio, S. Gupta, M. C. Young, Q. F. Marshall, S. E. Garfinkle, G. F. Papadaki, H. V. Truong, E. Mycek, P. Li, A. Farrel, N. L. Church, S. Jabar, M. D. Beasley, B. R. Kiefel, , N. G. Sgourakis
This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.
bioRxiv · May 24, 2023Biochemistry