WNK kinases sense molecular crowding and rescue cell volume via phase separation
C. R. Boyd-Shiwarski, D. J. Shiwarski, S. E. Griffiths, R. T. Beacham, L. Norrell, D. E. Morrison, J. Wang, J. R. Mann, W. Tennant, E. N. Anderson, J. Franks, M. Calderon, K. A. Connolly, C. J. Weaver, C. C. Weckerly, , A. R. Subramanya
This study shows WNK1 senses molecular crowding by phase separation to activate volume recovery in hypertonic conditions through phosphorylation-dependent signaling.
bioRxiv · Jan 10, 2022Cell Biology