Cell BiologybioRxiv
WNK kinases sense molecular crowding and rescue cell volume via phase separation
C. R. Boyd-Shiwarski, D. J. Shiwarski, S. E. Griffiths…·A. R. Subramanya
This study shows WNK1 senses molecular crowding by phase separation to activate volume recovery in hypertonic conditions through phosphorylation-dependent signaling.
DOI 10.1016/j.cell.2022.09.042