Author

S. Eising

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Assay:proteomics· 3 Organism:yeast· 3 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. J. Molenaar· 4 shared F. Froehlich· 3 shared J. DeMartino· 2 shared M. van de Wetering· 2 shared S. Walter· 2 shared V. Amo-Addae· 2 shared A. H. W. Essing· 1 shared A. Janse· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCancer Biology

J. J. Molenaar

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

D. Wilbie, S. Eising, V. Amo-Addae, J. Walther, E. Bosman, O. G. de Jong, J. J. Molenaar, E. Mastrobattista

This study screens cancer drugs to find those that enhance HDR over NHEJ in CRISPR gene editing, identifying Aurora kinase A inhibitors as promising candidates.

PLOS One · Sep 26, 2025Peer-reviewedPharmacology & Toxicology

Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

T. A. Kluiver, Y. Lu, S. A. Schubert, L. J. Kraaier, F. Ringnalda, P. Lijnzaad, J. DeMartino, W. L. Megchelenbrink, V. Amo-Addae, S. Eising, F. W. de Faria, D. J. Munter, M. van de Wetering, K. Kerl, E. Duiker, , W. C. Peng

This study identifies two hepatoblastoma subtypes with distinct WNT activation profiles and discovers drug sensitivities in patient-derived tumor organoids.

bioRxiv · Aug 28, 2023 · PreprintCancer Biology

Complex Sphingolipid Profiling and Identification of an Inositol Phosphorylceramide Synthase in Dictyostelium discoideum

S. A. Listian, M. Kol, E. Ufelmann, S. Eising, F. Froehlich, S. Walter, J. C. M. Holthuis, C. Barisch

This study identifies an inositol phosphorylceramide synthase in Dictyostelium discoideum, revealing its sphingolipid biosynthesis pathway and localization.

bioRxiv · Jul 7, 2023 · PreprintCell Biology

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

M. T. Meister, M. J. A. Groot Koerkamp, T. de Souza, W. B. Breunis, E. Frazer-Mendelewska, M. Brok, J. DeMartino, F. Manders, C. Calandrini, H. H. D. Kerstens, A. Janse, M. E. M. Dolman, S. Eising, K. P. S. Langenberg, M. van Tuil, , F. C. P. Holstege

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

bioRxiv · Jan 3, 2022Cancer Biology

Loss of p16INK4a in neuroblastoma cells induces shift to an immature state with mesenchymal characteristics and increases sensitivity to EGFR inhibitors

N. A. Schubert, S. R. van Hooff, L. Schild, K. Ober, M. Hortensius, K. van den Handel, A. H. W. Essing, B. Koopmans, M. Boeije, N. Proost, M. van de Ven, S. Jansky, S. A. Stainczyk, U. H. Toprak, F. Westermann, , M. L. van den Boogaard

bioRxiv · Oct 27, 2021 · PreprintCancer Biology

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways

S. Eising, B. M. Esch, M. Waelte, P. Vargas Duarte, S. Walter, C. Ungermann, M. Bohnert, F. Froehlich

The paper generates a lysosomal biogenesis map in yeast by combining proteomics and mutant analyses, revealing cargo-receptor relationships and novel CVT pathway cargo.

bioRxiv · Jul 24, 2021Cell Biology

Multiple roles for the ESCRT machinery in maintaining plasma membrane homeostasis

O. Schmidt, Y. Weyer, S. Sprenger, M. A. Widerin, S. Eising, V. Baumann, M. Angelova, R. Loewith, C. J. Stefan, M. W. Hess, F. Froehlich, D. Teis

This study investigates the role of ESCRT machinery in plasma membrane homeostasis using budding yeast, revealing its involvement in membrane tension regulation and sphingolipid metabolism through calcineurin/TORC2 signaling.

bioRxiv · Feb 25, 2020Cell Biology

A Systematic Approach to Identify Recycling Endocytic Cargo Depending on the GARP Complex

F. Fröhlich, S. Eising, L. Thiele

The paper identifies GARP complex-dependent recycling cargo in yeast using auxin-induced degradation and vacuolar proteomics/lipidomics.

bioRxiv · Oct 19, 2018Cell Biology