The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
Y. Weyer, S. I. Schwabl, X. Tang, M. A. Widerin, V. Niedrist, M. G. Tettamanti, S. Weys, B. Sarg, L. Kremser, K. R. Liedl, O. Schmidt, D. Teis
This study identifies the Dsc ubiquitin ligase complex as a quality control mechanism at the Golgi that degrades orphaned proteins by assessing transmembrane domain hydrophobicity.
bioRxiv · Mar 11, 2024Cell Biology