C. Ungermann

Structure of the endosomal CORVET tethering complex

The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.

Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation

Targeting of the Mon1-Ccz1 Rab guanine nucleotide exchange factor to distinct organelles by a synergistic protein and lipid code

The paper identifies a synergistic protein and lipid code that directs the Mon1-Ccz1 complex to distinct organelles, revealing how it differentially targets endosomes and autophagosomes.

Structure of the lysosomal membrane fusion machinery

This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.

Systematic assessment of the accuracy of subunit counting in biomolecular complexes using automated single molecule brightness analysis

This paper develops an automated computational pipeline to assess subunit counting accuracy in biomolecular complexes using single molecule brightness analysis across simulated and experimental data.

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways

The paper generates a lysosomal biogenesis map in yeast by combining proteomics and mutant analyses, revealing cargo-receptor relationships and novel CVT pathway cargo.