Mitochondrial Matrix Protease ClpP Agonists inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Y. E. Greer, L. Hernandez, E. M. J. Fennell, D. Voeller, R. Chari, S. F. Gilbert, B. Tang, M. Hafner, C. Annunziata, E. Iwanowicz, L. M. Graves, S. Lipkowitz
This study shows that ClpP agonists inhibit breast cancer stem cell function by disrupting mitochondrial homeostasis and multiple metabolic pathways.
bioRxiv · Mar 18, 2022Cancer Biology