A. Simon

Generation of diversity in the blue cheese mold Penicillium roqueforti and identification of pleiotropic QTL for key cheese-making phenotypes

This study identifies pleiotropic QTLs for key cheese-making traits in Penicillium roqueforti by analyzing F1 hybrids from cheese and non-cheese populations.

The contribution of gene flow, selection, and genetic drift to five thousand years of human allele frequency change

This study decomposes the contributions of gene flow, genetic drift, and linked selection to allele frequency change over 5,000 years using ancient human DNA datasets.

Marine transmissible cancer navigates urbanised waters, threatening to spillover

The paper investigates the spread of a transmissible cancer in mussels, finding higher prevalence in ports and suggesting human activities facilitate its transmission.

Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics

The paper introduces an ex vivo intestinal permeability assay (X-IPA) to quantify gut permeability dynamics and shows that specific microbes and metabolites induce rapid, dose-dependent increases in permeability.

Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2

This study identifies two siRNA combinations that provide robust prophylactic protection against SARS-CoV-2 in hamsters by reducing viral load and preventing lung pathology.

Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency

This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.

Low centrosome numbers correlate with higher aggressivity in ovarian cancer

The paper analyzes centrosome numbers in ovarian cancers and finds that low centrosome numbers correlate with poor patient survival and mesenchymal subgroup enrichment.

Genetic instability from a single S-phase after whole genome duplication

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

Prevalence and polymorphism of a mussel transmissible cancer in Europe

The paper screens European mussels for transmissible cancer lineages, finding low prevalence of MtrBTN2 and polymorphism suggesting complex diversification.

Drosophila neural stem cells show a unique dynamic pattern of gene expression that is influenced by environmental factors

The paper demonstrates dynamic, reversible silencing of GAL80 in Drosophila neural stem cells influenced by environmental factors, with implications for clonal experiments and brain mosaicism.

Secondary ossification center induces and protects growth plate structure

This study identifies the secondary ossification center's role in protecting growth plate hypertrophic chondrocytes from mechanical stress during terrestrial adaptation.

Population genomics reveals molecular determinants of specialization to tomato in the polyphagous fungal pathogen Botrytis cinerea

The paper identifies genomic features underlying host specialization in Botrytis cinerea populations adapted to tomato and grapevine.

How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels

The paper examines species barrier decay in mussels by analyzing introgression patterns and SNP concordance in hybrid zones.

DILS : Demographic Inferences with Linked Selection by using ABC

DILS performs demographic inferences with linked selection using ABC on population genomic data, identifying models and loci associated with gene flow and population size changes.

Trachomatous Trichiasis (TT) management in Tanzania: a mixed method study investigating barriers and facilitators to obtaining treatment

This paper investigates barriers and facilitators to TT treatment in Tanzania using mixed methods, finding 13% of TT cases unidentified and 72% lost in care continuum.

Replicated anthropogenic hybridisations reveal parallel patterns of admixture in marine mussels.

The paper studies hybridization patterns in marine mussels caused by human activity, finding repeatable genetic shifts and admixture patterns influenced by genetic background.

Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo

This study shows metastatic breast cancer cells alter microglial morphology and electrical activity in the brain, contributing to seizures and cognitive issues.

CELL CYCLE ASYNCHRONY GENERATES DNA DAMAGE AT MITOTIC ENTRY IN POLYPLOID CELLS

This study shows that polyploid cells generate DNA damage at mitotic entry due to cell cycle asynchrony, contributing to genetic instability in Drosophila and mouse neural stem cells.

First natural crossover recombination of intact ORFs between two distinct species of the family Closteroviridae

The paper identifies LCV-SP as the first natural crossover recombination of intact ORFs between two Closteroviridae species, showing recombination's role in viral evolution.

Coadapted genomes and selection on hybrids: Fisher’s geometric model explains a variety of empirical patterns

The paper develops a fitness landscape model to explain hybridization patterns across species, supported by genomic data from multiple organisms.