Cell BiologybioRxivPreprint
Progerin triggers a phenotypic switch in vascular smooth muscle cells that causes replication stress and an aging-associated secretory signature
N. Coll-Bonfill, U. Mahajan, C.-J. Lin…·S. Gonzalo
This study shows that progerin induces a phenotypic switch in vascular smooth muscle cells, causing replication stress and an aging-associated secretory signature, contributing to vascular stiffness in progeria.