Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1
D. Johnson, S. Colijn, J. Richee, J. Yano, M. Burns, A. E. Davis, V. N. Pham, A. Saric, A. Jain, Y. Yin, D. Castranova, M. Melani, M. Fujita, S. Grainger, J. S. Bonifacino, , A. N. Stratman
This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.
bioRxiv · Apr 1, 2024Cell Biology