Author

S. Grzesiek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Grahl· 2 shared P. Isaikina· 2 shared T. Maier· 2 shared A. K. Shukla· 1 shared A. Maier· 1 shared A. Ranjan· 1 shared C.-J. Tsai· 1 shared F. Pamula· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiophysics

A. Grahl

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4 papers

Recent·Most cited

BiophysicsbioRxivOct 4, 2023

The molecular basis of Abelson kinase regulation by its αI-helix

J. Paladini, A. Maier, J. M. Habazettl…·S. Grzesiek

This study identifies how the αI-helix modulates Abl kinase activity through mechanical forces affecting the KD/SH2SH3 interface, with implications for drug response.

DOI 10.7554/elife.92324

mechanistic / dynamical modelchromatin & epigenetic regulation

BiophysicsbioRxivPreprintOct 10, 2022

A key GPCR phosphorylation motif discovered in arrestin2-CCR5 phosphopeptide complexes

P. Isaikina, I. Petrovic, R. P. Jakob…·S. Grzesiek

The paper identifies a phosphorylation motif in arrestin2-CCR5 complexes that is essential for stable interactions and functional activation of CCR5.

DOI 10.1101/2022.10.10.511578

humanstructural biology

BiophysicsbioRxivAug 30, 2021

Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol

L. A. Abiko, R. Dias Teixeira, S. Engilberge…·S. Grzesiek

The paper identifies dry voids in the β1-adrenergic receptor that cholesterol fills, explaining its allosteric regulation and suggesting new drug development strategies.

DOI 10.1038/s41557-022-01009-9

humanstructural biology

BiophysicsbioRxivNov 27, 2020

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

P. Isaikina, C.-J. Tsai, N. B. Dietz…·S. Grzesiek

The paper reports the cryo-EM structure of CCR5 bound to a chemokine agonist and Gi protein, revealing its activation mechanism.

DOI 10.1126/sciadv.abg8685

humancryo-EM