T. Maier

The origin, deployment, and evolution of a plant-parasitic nematode effectorome

This study identifies and characterizes the effectorome of the plant-parasitic nematode Heterodera schachtii, revealing 659 effector gene loci and providing insights into their origin, deployment, and evolution.

A Novel Biosensor Reveals Dynamic Changes of C-di-GMP in Differentiating Cells with Ultra-High Temporal Resolution

This paper introduces a genetically-encoded c-di-GMP biosensor, cdGreen2, capable of tracking c-di-GMP dynamics in live cells with ultra-high temporal resolution.

A key GPCR phosphorylation motif discovered in arrestin2-CCR5 phosphopeptide complexes

The paper identifies a phosphorylation motif in arrestin2-CCR5 complexes that is essential for stable interactions and functional activation of CCR5.

Catalytic cycling of human mitochondrial Lon protease

This study characterizes the mechanism of human mitochondrial LonP1 protease using cryo-EM, revealing its conformational states and a new proteolytic center.

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

The paper reports the cryo-EM structure of CCR5 bound to a chemokine agonist and Gi protein, revealing its activation mechanism.

The 3.2A resolution structure of human mTORC2

This study presents a 3.2 Å resolution cryo-EM structure of human mTORC2, revealing structural features and regulatory mechanisms.

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.

Structural basis for ion selectivity in TMEM175 K+ channels

This study determines the X-ray structure of a bacterial TMEM175 K+ channel, revealing a unique cation-selective mechanism involving a conserved threonine residue and conformational changes.

DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations

This paper generates DARPins targeting mTFP1 and uses them to delocalize Rab proteins in cultured cells, demonstrating potential for direct protein manipulation in vivo.