The molecular basis of Abelson kinase regulation by its αI-helix
J. Paladini, A. Maier, J. M. Habazettl, I. Hertel, R. Sonti, S. Grzesiek
This study identifies how the αI-helix modulates Abl kinase activity through mechanical forces affecting the KD/SH2SH3 interface, with implications for drug response.
bioRxiv · Oct 4, 2023Biophysics