A. Ranjan

Cyclin A2 Induces Cytokinesis in Human Adult Cardiomyocytes and Drives Reprogramming in Mice

This study shows that Cyclin A2 induces cytokinesis in adult human cardiomyocytes and drives reprogramming in mice through transcriptomic analysis.

Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors

This study presents cryo-EM structures and experimental data revealing how beta-arrestins interact with GPCRs, particularly those with phosphorylation in the third intracellular loop and intrinsically biased receptors.

Peripheral vascular strand development in nodules is controlled by a bHLH/HLH heterodimer

This study identifies NVD1 and NVD2 heterodimers as critical regulators of peripheral vascular strand development in Medicago truncatula nodules, showing their role in maintaining proper vascular organization and auxin/cytokinin balance.

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

Partial Activation of PPAR-gamma by Synthesized Quercetin Derivatives Modulates TGF-beta-Induced EMT in Lung Cancer cells

This study shows that partial PPAR-gamma activation by synthesized quercetin derivatives inhibits TGF-beta1-induced EMT and migration in lung cancer cells.

A key GPCR phosphorylation motif discovered in arrestin2-CCR5 phosphopeptide complexes

The paper identifies a phosphorylation motif in arrestin2-CCR5 complexes that is essential for stable interactions and functional activation of CCR5.

Design, synthesis and biological evaluation of novel quercetin derivatives as PPAR-γ partialagonists by modulating Epithelial-mesenchymal transition in lung cancer metastasis

This study synthesizes and evaluates novel quercetin derivatives as PPAR-γ partial agonists that inhibit EMT in lung cancer cells.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Transcriptome analysis reveals robust transcriptional reprogramming during early stages of Cicer-Ascochyta interaction

This study compares transcriptional responses of AB-resistant and susceptible chickpea genotypes to A. rabiei infection, identifying key pathways and hub genes involved in resistance.

Molecular basis of differential adventitious rooting competence in poplar genotypes

The paper identifies molecular differences in adventitious rooting competence between two poplar genotypes and shows that MYC2 expression levels influence rooting ability.

High temperature limits leaf size via direct control of cell cycle by coordinated functions of PIF4 and TCP4

High ambient temperature suppresses Arabidopsis leaf area by reducing cell proliferation through PIF4- and TCP4-dependent regulation of KRP1 transcription.

ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

This study shows ATP binding enables SWR1 chromatin remodeler to diffuse along DNA, facilitating efficient target search by sliding over DNA until encountering roadblocks.

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.

Coordinated DNA and Histone Dynamics Drive Accurate Histone H2A.Z Exchange

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

High photosynthesis rate in the selected wild rice is driven by leaf anatomy mediating high Rubisco activity and electron transport rate

The paper identifies wild rice accessions with high photosynthesis rates, linking this to anatomical features and biochemical factors like Rubisco activity and electron transport rate.

CaProDH2-mediated modulation of proline metabolism confers tolerance to Ascochyta in chickpea under drought

This study identifies CaProDH2 as a key gene in the proline-P5C cycle that enhances chickpea resistance to Ascochyta rabiei under drought conditions.

Sucrose transport and metabolism control carbon partitioning between stem and grain in rice

This study compares the source-sink dynamics between cultivated rice and wild rice, identifying vascular features, sucrose transport, and sugar metabolic enzyme activity as factors influencing biomass and grain yield differences.

Spatial control of cell division by GA-OsGRF7/8 module in a leaf explains the leaf length variation between cultivated and wild rice

The paper identifies GA and OsGRF7/8's role in controlling cell division in rice leaves, explaining differences in leaf length between cultivated and wild rice.

HYPK scaffolds the Nedd8 and LC3 proteins to initiate formation of autophagosome around polyneddylated huntingtin exon1 aggregates

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

Measuring DNA mechanics on the genome scale

This paper develops loop-seq to measure DNA bendability genome-wide and finds sequence-encoded low bendability upstream of TSSs that influences nucleosome positioning and chromatin remodeling.

Red light controls adventitious root regeneration by modulating hormone homeostasis in Picea abies seedlings

This study shows red light promotes adventitious root initiation in Norway spruce seedlings by modulating hormone homeostasis, specifically reducing jasmonate and cytokinin levels.

Semecarpus anacardium Linn. leaf extract exhibits activities against breast cancer and prolongs the survival of tumor-bearing mice

This study shows that Semecarpus anacardium leaf extract inhibits breast cancer cell growth and extends survival in tumor-bearing mice.

The dual function receptor kinase, OsWAKL21.2, is involved in elaboration of lipaseA/esterase induced immune responses in rice

This study identifies OsWAKL21.2 as a rice receptor kinase that senses cell wall damage from Xanthomonas secreted enzymes to trigger immune responses.

Molecular framework for TIR1/AFB-Aux/IAA-dependent auxin sensing controlling adventitious rooting in Arabidopsis

The paper identifies TIR1 and AFB2 as positive regulators and IAA6, IAA9, and IAA17 as negative regulators of adventitious root formation in Arabidopsis, revealing their role in modulating jasmonate homeostasis.

Integrated soybean transcriptomics, metabolomics, and chemical genomics reveal the importance of the phenylpropanoid pathway and antifungal activity in resistance to the broad host range pathogen Sclerotinia sclerotiorum

This study identifies resistance mechanisms in soybean against Sclerotinia sclerotiorum using multi-omics approaches, showing the role of jasmonate signaling, ROS scavenging, and phenylpropanoid pathway reprogramming in antifungal defense.

Decoding the gene co-expression network underlying the ability of Gevuina avellana Mol. to live in diverse light conditions

The paper identifies a gene co-expression network in Gevuina avellana that supports its ability to maintain optimal photosynthetic performance across diverse light conditions.