S. J. Altschuler

This paper introduces a compound-first approach to natural product discovery called SMIRC, which captures structurally complex small molecules directly from environments, leading to the discovery of new compounds and classes.

The paper identifies that modulating transit-amplifying cell proliferation alters intestinal epithelial cell-type composition through lineage-based mechanisms.

The paper models cell-to-cell communication networks using response-time distributions to explain cytokine secretion onset times in T cells and predict network structure from input-output measurements.