Author

S. J. Horton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

G. Giotopoulos· 4 shared D. Sasca· 3 shared E. Meduri· 3 shared H. Yun· 3 shared B. J. P. Huntly· 2 shared F. Basheer· 2 shared J. Bagri· 2 shared P. Gallipoli· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

G. Giotopoulos

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2023

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

A. Garcia-Gimenez, J. E. Ditcham, D. M. A. Azazi…·S. E. Richardson

This study identifies CREBBP mutations as a targetable vulnerability in B-ALL, showing that CREBBP inhibition sensitizes these cells to Venetoclax-induced ferroptosis.

DOI 10.1101/2023.10.02.556536

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 12, 2022

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

S. Agrawal Singh, J. Bagri, G. Giotopoulos…·B. J. P. Huntly

This study identifies a repressive HOXA9-SAFB complex in AML that maintains disease by inhibiting differentiation and apoptosis, suggesting therapeutic targets.

DOI 10.1101/2022.10.12.511919

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 14, 2022

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation

V. Shah, G. Giotopoulos, H. Osaki…·D. Sasca

This study identifies p300-mediated compensatory transcriptional programs that drive acute resistance to BET inhibitors in AML and suggests sequential BET- and p300-inhibition as a therapeutic strategy.

DOI 10.1101/2022.09.14.507850

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivMar 20, 2020

Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction

H. Yun, S. Vohra, A. Mupo…·B. J. P. Huntly

The paper investigates how mutations synergize to alter chromatin accessibility, enhancer landscapes, and 3D DNA topology in leukemia induction using a murine model.

DOI 10.1038/s41588-021-00925-9

mouseChIP-seq

𝕏 PostBluesky