Author

S. J. Polyak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Ianevski· 1 shared A. Matukevicius· 1 shared A. Vitkauskiene· 1 shared D. A. Fidock· 1 shared D. E. Kainov· 1 shared D. J. Filman· 1 shared D. Rowlands· 1 shared E. Lastauskiene· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Ianevski

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate.

N. J. Kingston, J. S. Snowden, K. Grehan, P. K. Hall, E. V. Hietanen, T. C. Passchier, S. J. Polyak, D. J. Filman, J. M. Hogle, D. Rowlands, N. J. Stonehouse

The paper determines the molecular mechanism of VP0 cleavage in enteroviruses using structural and bioinformatic analysis of a provirion intermediate.

bioRxiv · Apr 6, 2024Microbiology

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

A. Ianevski, R. Yao, R. M. Simonsen, V. Myhre, E. Ravlo, G. D. Kaynova, E. Zusinaite, J. M. White, Q. Pan, S. J. Polyak, V. Oksenych, M. P. Windisch, E. Lastauskiene, A. Vitkauskiene, A. Matukevicius, , D. E. Kainov

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

bioRxiv · Jan 15, 2022 · PreprintMicrobiology

Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

M. S. Nair, Y. Huang, D. A. Fidock, S. J. Polyak, J. Wagoner, M. Towler, P. Weathers

This study shows that Artemisia annua extracts inhibit SARS-CoV-2 and its variants in vitro, with antiviral activity not linked to artemisinin or flavonoids, and suggests potential therapeutic use.

bioRxiv · Jan 8, 2021Microbiology