D. A. Fidock

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

The paper identifies mixed alkyl/aryl phosphonates as anti-malarial compounds that inhibit serine hydrolases with low resistance potential.

Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

This study creates a mutator parasite of Plasmodium falciparum to enhance drug resistance discovery by increasing mutation rates and identifying resistance mechanisms.

Artemisia annua hot-water extracts show potent activity in vitro against Covid-19 variants including delta

This study evaluates the anti-SARS-CoV-2 activity of Artemisia annua hot-water extracts against multiple variants, finding potent efficacy with low toxicity.

Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

This study examines K13 mutations in Plasmodium falciparum, showing varying degrees of artemisinin resistance and fitness costs in African parasites, while finding no significant impact on ART susceptibility in Southeast Asian strains.

Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

This study shows that Artemisia annua extracts inhibit SARS-CoV-2 and its variants in vitro, with antiviral activity not linked to artemisinin or flavonoids, and suggests potential therapeutic use.

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That is Reversed by Proteasome Inhibition

This study introduces K13 mutations into Plasmodium berghei to demonstrate their role in mediating artemisinin resistance in vivo, showing delayed parasite clearance and synergistic effects with proteasome inhibitors.

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

Genetic screens reveal a central role for heme biosynthesis in artemisinin susceptibility

The paper uses CRISPR screens to identify genetic factors affecting artemisinin susceptibility in apicomplexan parasites, revealing heme biosynthesis as a key pathway.

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.