Q. Pan

Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma

This study identifies pyrvinium pamoate as a potential therapy for Merkel cell carcinoma by targeting Wnt signaling and multiple cancer vulnerabilities.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer's Disease

This paper demonstrates that CAR-Ms engineered to secrete M-CSF can target and reduce amyloid plaques in a mouse model of Alzheimer's disease.

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

Anthracyclines inhibit SARS-CoV-2 infection

This study identifies anthracyclines as potential SARS-CoV-2 inhibitors through a microbial metabolite screening effort, showing they inhibit viral infection via different mechanisms.

Thyroid hormone-dependent apoptosis during metamorphosis in Ciona robusta involves both bilaterian-ancestral and vertebrate-derived processes

This study investigates thyroid hormone-dependent apoptosis during metamorphosis in Ciona robusta, showing similarities to other chordates but with distinct molecular mechanisms.

Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammals

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

SARS-CoV-2 accessory protein ORF8 decreases antibody-dependent cellular cytotoxicity

This study shows that SARS-CoV-2 accessory protein ORF8 reduces antibody-dependent cellular cytotoxicity by binding CD16a and decreasing CD16 surface levels on monocytes and NK cells.

Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses

This study shows that nuclear import of Gdown1 modulates global transcription and enhances cellular stress tolerance.

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

Genome-wide CRISPR activation screen identifies novel receptors for SARS-CoV-2 entry

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

Lipophilic Nanocrystal Prodrug-Release Defines the Extended Pharmacokinetic Profiles of a Year-Long Cabotegravir

This study demonstrates that a nanoformulated CAB prodrug (NM2CAB) maintains plasma levels above the inhibitory concentration for up to one year, with sustained drug retention in tissues and macrophages.

miR-424(322) is a molecular switch controlling pro-inflammatory vs anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling

This study identifies miR-424(322) as a molecular switch that controls the differentiation of pro-inflammatory monocyte-derived DCs (moDCs) versus anti-inflammatory Langerhans cells (LCs) by modulating TGF-β signaling.

Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to construct pluripotency gene regulatory network

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

Artificial light at night amplifies seasonal relapse of haemosporidian parasites in a widespread songbird

This study shows artificial light at night increases parasitemia and desynchronizes immune responses in dark-eyed juncos, leading to seasonal relapse of chronic haemosporidian infections.

The rise and fall of the ancient northern pike master sex determining gene

The paper traces the evolution of sex determination in northern pike, revealing an ancient origin of the master sex-determining gene and recent transitions including Y-chromosome loss.

Tracing two causative SNPs reveals SARS-CoV-2 transmission in North America population

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation

The paper identifies and functionally validates an ancient duplicated anti-Mullerian hormone gene as the master sex determining gene in Northern pike, revealing limited sex chromosome differentiation.

Hydrogen sulfide promotes nodulation and nitrogen fixation in soybean-rhizobia symbiotic system

This study shows that hydrogen sulfide promotes nodulation and nitrogen fixation in soybean-rhizobia symbiosis by upregulating key genes and proteins involved in symbiosis and nitrogen metabolism.

Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity

This study develops RNA aptamers targeting CEA, CA50, and CA72-4 with high affinity and specificity, showing potential for improved cancer detection and therapy.