R. Yao

Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection

This study shows that Mmp17-deficient mice have increased goblet cell effector genes and resistance to Trichuris muris infection without changes in traditional immune modulators.

Targeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen

This paper develops a targeted photodynamic approach to neutralize SARS-CoV-2 by enhancing antibody efficacy through singlet oxygen generation.

Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

This study shows that Prdm13 signaling in the dorsomedial hypothalamus affects age-related sleep-wake changes in mice, and dietary restriction can mitigate these effects.

Toxicity of microplastics and plastic additive co-exposure in liver Disse organoids from healthy donors and patient-derived induced pluripotent stem cells

This study uses hiPSC-derived organoids to show that co-exposure to microplastics and TBBPA increases toxicity in patient-derived organoids compared to healthy ones.

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

Active components of commonly prescribed medicines affect influenza A virus-host cell interaction: a pilot study

This study examines how active components of commonly prescribed medicines affect influenza A virus-host cell interactions both in silico and in vitro.

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

Identification of novel antiviral drug combinations in vitro and tracking their development

This study identifies novel synergistic antiviral drug combinations effective against SARS-CoV-2, echovirus 1, HCV, and HIV-1 in vitro and provides an online resource for their developmental status.

Accelerating Monte Carlo modeling of structured-light based diffuse optical imaging via "photon sharing"

This paper introduces an efficient Monte Carlo method for simulating spatially modulated light transport in 3D domains, achieving significant speedups in both forward and inverse problems.

Potential antiviral options against SARS-CoV-2 infection

The paper identifies potent convalescent sera and broad-spectrum antivirals effective against SARS-CoV-2 using a neutralization assay and cell culture screening.

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

This study shows that XLF is functionally redundant with MRI and PAXX in lymphocyte development, and Mri interacts genetically with Dna-pkcs and Paxx in mice.

Deep Learning Enhanced Hyperspectral Fluorescence Lifetime Imaging

This paper introduces a deep learning framework for fast hyperspectral fluorescence lifetime imaging, achieving rapid acquisition and processing without training data.

Ultra-fast fit-free analysis of complex fluorescence lifetime imaging via deep learning

This paper introduces FLI-Net, a deep learning model that enables ultra-fast, fit-free analysis of fluorescence lifetime imaging data across multiple spectral ranges and acquisition technologies.

Lsm12 mediates Polη deubiquitination to help Saccharomyces cerevisiae resist oxidative stress

This study identifies Lsm12 as a regulator that mediates Polη deubiquitination to enhance its recruitment and improve survival under oxidative stress in yeast.

Transit and integration of extracellular mitochondria in human heart cells

This study shows that exogenous mitochondria can be internalized and integrated into human cardiac cells, improving energy production and reducing cell death after ischemic injury.