Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas
J. E. Himes, A. J. Wisdom, L. Wang, S. J. Shepard, A. R. Daniel, N. Williams, L. Luo, Y. Ma, Y. M. Mowery, D. G. Kirsch
This study develops an autochthonous murine sarcoma model and shows that both CD8 and CD4 T cells are required for immunosurveillance against neoantigen-expressing tumors.
bioRxiv · Apr 4, 2023 · PreprintCancer Biology