N. Williams

The long-term effects of chemotherapy on normal blood cells

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

56Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice

This study shows that 56Fe ion exposure increases lung and brain tumor incidence similarly in male and female mice, with 56Fe ions causing faster tumor development than X-rays.

Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas

This study develops an autochthonous murine sarcoma model and shows that both CD8 and CD4 T cells are required for immunosurveillance against neoantigen-expressing tumors.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

Integration of microprism and microelectrode arrays enables simultaneous electrophysiology and two-photon imaging across all cortical layers

This paper introduces a device combining microelectrodes and microprisms for simultaneous electrophysiology and two-photon imaging across all cortical layers in mice.

Restoration and resilience to sea level rise of a salt marsh affected by dieback events in Charleston, SC

This study shows that salt marshes in Charleston, SC, have not fully recovered 10 years after dieback events, highlighting the need for restoration and climate change mitigation.

Optimizing the live attenuated influenza A vaccine backbone for high-risk patient groups

This study modifies the LAIV backbone to enhance safety while maintaining immunogenicity, showing reduced replication and no loss of protective efficacy.

The longitudinal dynamics and natural history of clonal haematopoiesis

This study tracks clonal haematopoiesis clones over time, finding that mutation type influences growth rates and malignant risk.

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution

This study reconstructs the phylogeny of myeloproliferative neoplasms using whole-genome sequencing, revealing early mutation acquisition and lifelong clonal evolution leading to cancer.

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

Machine learning predicts rapid relapse of triple negative breast cancer

The paper uses machine learning to predict rapid relapse of triple-negative breast cancer based on clinical and genomic features.

Zika Virus Subverts Stress Granules to Promote and Restrict Viral Gene Expression

This study investigates how Zika virus disrupts stress granule formation and modulates viral gene expression by relocalizing specific stress granule proteins.

Genome-Wide Fitness Analyses of the Foodborne Pathogen Campylobacter jejuni in In Vitro and In Vivo Models

This study identifies genes essential for Campylobacter jejuni growth and survival across multiple in vitro and in vivo conditions using transposon sequencing.