A. J. Wisdom

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

Loss of function of Atrx leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma

This study shows that loss of Atrx in a mouse sarcoma model activates the ALT telomere maintenance pathway independently of telomerase, leading to telomere instability and APB formation.

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas

This study develops an autochthonous murine sarcoma model and shows that both CD8 and CD4 T cells are required for immunosurveillance against neoantigen-expressing tumors.

The Na+/K+ ATPase Regulates Glycolysis and Modifies Immune metabolism in Tumors

This study shows that Na+/K+ ATPase inhibition via digoxin disrupts glycolysis in tumor and healthy cells, alters immune metabolism, and changes tumor microenvironment composition.

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.