BiochemistrybioRxiv
Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant
S. K. Gersing, Y. Wang, M. Gronbaek-Thygesen…·R. Hartmann-Petersen
This study investigates the degradation pathway of a disease-linked ASPA variant, finding it is degraded via the proteasome and dependent on Hsp70 and Hsp110.
DOI 10.1371/journal.pgen.1009539