Topology of connective tissues: a key parameter in cellular heterogeneity, beyond composition and stiffness
C. Chen, Z. Ibrahim, M. F. Marchand, T. Piolot, S. Kamboj, F. Carreiras, A. Yamada, M. C. Schanne Klein, Y. Chen, A. Lambert, C. Aime
This study creates ECM models with varied topology, composition, and stiffness to study their impact on cellular phenotypes, showing EMT shifts are multidimensional and not solely dependent on single ECM features.
bioRxiv · Jan 26, 2022 · PreprintBioengineering