Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection
L. Echavarria-Consuegra, G. M. Cook, I. Busnadiego, C. Lefevre, S. Keep, K. Brown, N. Doyle, G. Dowgier, K. Franaszek, N. A. Moore, S. G. Siddell, E. Bickerton, B. G. Hale, A. E. Firth, I. Brierley, N. Irigoyen
This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.
bioRxiv · Mar 19, 2021Microbiology