Author

I. Brierley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. M. Cook· 3 shared A. E. Firth· 2 shared A. M. Dinan· 2 shared C. Lefevre· 2 shared K. Brown· 2 shared L. Echavarria-Consuegra· 2 shared N. Irigoyen· 2 shared A. Lakatos· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

G. M. Cook

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

C. Lefevre, G. M. Cook, A. M. Dinan, S. Torii, H. Stewart, G. Gibbons, A. S. Nicholson, L. Echavarria-Consuegra, L. W. Meredith, V. Lulla, J. C. Kenyon, I. G. Goodfellow, J. E. Deane, S. C. Graham, A. Lakatos, , N. Irigoyen

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

G. M. Cook, K. Brown, P. Shang, Y. Li, L. Soday, A. M. Dinan, C. Tumescheit, A. P. A. Mockett, Y. Fang, A. E. Firth, I. Brierley

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

bioRxiv · Nov 17, 2021Pathology

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

L. Echavarria-Consuegra, G. M. Cook, I. Busnadiego, C. Lefevre, S. Keep, K. Brown, N. Doyle, G. Dowgier, K. Franaszek, N. A. Moore, S. G. Siddell, E. Bickerton, B. G. Hale, A. E. Firth, I. Brierley, N. Irigoyen

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

bioRxiv · Mar 19, 2021Microbiology