BiophysicsbioRxivPreprint
Nuclear activation in dual-durotaxing cells on a matrix with cell-scale stiffness-heterogeneity
S. Kidoaki, H. Ebata, K. Moriyama…·K. Tanaka
This study shows that mesenchymal stem cells undergoing dual-durotaxis on stiff micro-patterned gels experience amplified intracellular stress dynamics and chromatin fluctuations, which enhance cellular vigor and maintain stemness.
DOI 10.1101/2021.10.30.466554