Author

S. Kregel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. Budreika· 1 shared A. M. Chinnaiyan· 1 shared A. T. Cheung· 1 shared B. L. McCollum· 1 shared C. A. Mesaros· 1 shared C. Loitz· 1 shared C. Richter· 1 shared D. J. Vander Griend· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Budreika

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Author profile →

3 papers

Recent·Most cited

Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies

R. J. Kostlan, J. T. Phoenix, A. Budreika, M. G. Ferrari, N. Khurana, J. E. Choi, K. Juckette, B. L. McCollum, R. Moskal, Y. Qiao, D. J. Vander Griend, A. M. Chinnaiyan, S. Kregel

This paper develops humanized mouse models of metastatic prostate cancer to evaluate therapies, showing improved immune interactions and response to hormonal and immunotherapies.

bioRxiv · Oct 13, 2023 · PreprintCancer Biology

Regulation of prostate androgens by megalin and 25-hydroxyvitamin D status: Mechanism for high prostate androgen in African American men

J. Garcia, K. Krieger, C. Loitz, L. M. Perez, Z. A. Richards, Y. B. Helou, S. Kregel, S. Selada, C. A. Mesaros, P. Gann, T. E. Willnow, D. Vander Griend, R. Kittles, G. Prins, T. Penning, L. Nonn

This study shows megalin regulates prostate androgen levels by importing testosterone bound to sex hormone-binding globulin, and 25-hydroxyvitamin D suppresses megalin, linking vitamin D deficiency to higher prostate androgens in African American men.

bioRxiv · Nov 9, 2021Cancer Biology

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

J. H. Hwang, R. Arafeh, J.-H. Seo, S. C. Baca, M. Ludwig, T. E. Arnoff, C. Richter, H. E. Bergom, S. McSweeney, J. P. Rennhack, S. A. Klingenberg, A. T. Cheung, J. Kwon, J. So, S. Kregel, , W. Hahn

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

bioRxiv · Aug 18, 2021Cancer Biology