S. L. Sawyer

The paper investigates how CD4 receptor variants in gorillas and chimpanzees confer resistance to SIVs, showing that selective pressure shaped these variants to block viral entry.

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

The paper shows RNase L inhibits viral protein synthesis by blocking mRNA export rather than degrading viral mRNA, and regulates antiviral cytokine production.

The paper shows that natural selection on nucleoporin genes in yeast affects retrotransposon control without compromising essential nuclear pore functions.