J. M. Burke

This study identifies dRIFs as antiviral condensates containing OAS3, RNase L, and PKR, showing their role in RNase L activation during viral infection.

The paper examines how leaf traits in sunflower respond to drought stress and identifies key traits that predict plant performance under varying water availability.

This study identifies genomic regions and traits linked to nitrogen utilization efficiency and stress tolerance in sunflower under varying nutrient conditions.

The paper identifies genomic regions associated with major axes of variation in sunflower leaf traits related to gas exchange and leaf construction using genome-wide association analyses.

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

The paper shows that dsRNA induces the formation of cytosolic condensates (dRIFs) that enhance PKR activation, leading to translational arrest and stress granule formation.

The paper degrades RNA in the cytoplasm or nucleus to assess its role in maintaining RNP granules, finding that most are affected while some remain unchanged.

The paper identifies paracrine granules as distinct from stress granules, induced by viral infection and linked to antiviral activity.

The paper compares transcriptomic differences between sunflower populations from Texas and Saskatchewan to understand how seed oil composition varies with latitude.

This study shows SARS-CoV-2 infection inhibits IFN mRNA biogenesis and export by blocking nuclear-cytoplasmic transport and triggering mRNA degradation.

The paper shows RNase L inhibits viral protein synthesis by blocking mRNA export rather than degrading viral mRNA, and regulates antiviral cytokine production.

The paper identifies traits and genes associated with salinity tolerance in sunflower that are distinct from those linked to vigor, enabling improved tolerance without compromising growth.

The paper identifies large haplotype blocks associated with ecotypic differentiation in sunflowers, showing how structural variation maintains adaptive alleles despite hybridization.

The paper shows RNase L reprograms translation by degrading most mRNAs but allowing antiviral mRNAs like IFN-β to escape degradation during dsRNA stress.

This study shows that murine polyomavirus miRNAs reduce viral replication during persistent infection and promote viruria during acute infection, linking miRNA activity to immune evasion.