Author

C. Warren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:Xenopus· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Organism:chicken / avian· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

D. Shechter· 2 shared A. Barbachano-Guerrero· 1 shared A. Fiser· 1 shared A. Stabell· 1 shared B. M. Lorton· 1 shared C. M. Rive· 1 shared C. R. Merritt· 1 shared C. S. Hughes· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

D. Shechter

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses

C. Warren, A. Barbachano-Guerrero, V. DuMont, A. Stabell, O. Dirasantha, Q. Yang, S. L. Sawyer

The paper investigates how CD4 receptor variants in gorillas and chimpanzees confer resistance to SIVs, showing that selective pressure shaped these variants to block viral entry.

bioRxiv · Nov 13, 2023Microbiology

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency

B. M. Lorton, C. Warren, H. Ilyas, P. Nandigrami, S. Hegde, S. Cahill, S. M. Lehman, J. Shabanowitz, D. Hunt, A. Fiser, D. Cowburn, D. Shechter

The paper shows that glutamylation of acidic IDRs in Npm2 and Nap1 enhances their DNA mimicry function, improving histone chaperone efficiency in nucleosome assembly.

bioRxiv · Sep 18, 2023Biochemistry

Structure of the human ATM kinase and mechanism of Nbs1 binding

C. Warren, N. P. Pavletich

The paper reports cryo-EM structures of human ATM kinase and its complex with the Nbs1 FxF/Y motif, revealing an allosteric activation mechanism.

bioRxiv · Oct 17, 2021Biochemistry

Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations

C. M. Rive, E. Yung, C. S. Hughes, S. D. Brown, G. Sharma, L. Dreolini, N. M. Mawji, C. Warren, J. Karasinska, J. M. Loree, D. T. Yapp, G. B. Morin, D. J. Renouf, D. F. Schaeffer, S. Turcotte, R. A. Holt

The paper identifies and characterizes T cell receptors specific for HLA-A*02:01-restricted KRAS codon 12 mutations in cancer, showing their reactivity and cytotoxic activity against tumor cells.

bioRxiv · Jun 15, 2020 · PreprintImmunology

Structure of a Single Chain H2A/H2B Dimer

C. Warren, J. B. Bonanno, S. C. Almo, D. Shechter

The paper creates a single-chain H2A/H2B dimer and determines its structure, showing it resembles nucleosomal H2A/H2B, providing a tool for studying H2A/H2B-interacting proteins.

bioRxiv · Mar 15, 2020Biochemistry

High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods

C. R. Merritt, G. T. Ong, S. Church, K. Barker, G. Geiss, M. Hoang, J. Jung, Y. Liang, J. McKay-Fleisch, K. Nguyen, K. Sorg, I. Sprague, C. Warren, S. Warren, Z. Zhou, , J. M. Beechem

This paper introduces Digital Spatial Profiling (DSP), a method for high-plex spatial analysis of proteins and RNA in tissue, and demonstrates its application in studying immune and cancer microenvironments.

bioRxiv · Feb 26, 2019 · PreprintPathology