Author

S. Leone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

C. Busonero· 3 shared F. Acconcia· 3 shared A. Barthelemy· 1 shared A. E. Willis· 1 shared A. Herrero-Ruiz· 1 shared A. Sacchi· 1 shared A. Srivastava· 1 shared B. Hummel· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersCancer Biology

C. Busonero

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Bromodomain proteins as new drug target for an inborn lysosomal defect

M. Parente, A. Barthelemy, C. Tonini, S. Caputo, A. Sacchi, S. Leone, M. Segatto, F. W. Pfrieger, V. Pallottini

This study investigates bromodomain proteins as a therapeutic target for Niemann-Pick type C disease, showing that JQ1 improves NPC1 levels and reduces cholesterol accumulation in patient-derived fibroblasts.

bioRxiv · Dec 19, 2023Cell Biology

HSP70 binds to specific non-coding RNA and regulates human RNA Polymerase III

S. Leone, A. Srivastava, B. Hummel, L. Tittel, F. Aprile-Garcia, A. Herrero-Ruiz, P. Rawat, A. E. Willis, R. Sawarkar

This study identifies HSP70's interaction with non-coding RNA transcribed by RNA Polymerase III and shows its role in facilitating transcription of these RNAs.

bioRxiv · Apr 10, 2023Biochemistry

Evolution of the ribbon-like organization of the Golgi apparatus in animal cells

G. Benvenuto, S. Leone, E. Astoricchio, S. Bormke, S. Jasek, E. D'Aniello, M. Kittelmann, K. McDonald, V. Hartenstein, V. Baena, H. Escriva, S. Bertrand, B. Schierwater, P. Burkhardt, I. Ruiz-Trillo, , F. Ferraro

This study investigates the evolutionary origin of the Golgi ribbon in animal cells, identifies a molecular mechanism for its formation, and suggests its role in development.

bioRxiv · Feb 16, 2023Cell Biology

Neuromuscular embodiment of feedback control elements in Drosophila flight

S. C. Whitehead, S. Leone, T. Lindsay, M. R. Meiselman, N. Cowan, M. H. Dickinson, N. Yapici, D. L. Stern, T. Shirangi, I. Cohen

This study identifies how specific Drosophila flight muscles modulate elements of a proportional-integral controller during pitch stabilization.

bioRxiv · Feb 22, 2022Animal Behavior & Cognition

Real-time measurement of E2:ERα transcriptional activity in living cells.

M. Cipolletti, S. Leone, S. Bartoloni, C. Busonero, F. Acconcia

This study develops stable cell lines to monitor real-time ERα transcriptional activity in response to E2 and identifies biphasic dynamics and dose-dependent effects.

bioRxiv · Jan 11, 2020Physiology

In silico screening for ERα downmodulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells

C. Busonero, S. Leone, F. Bianchi, F. Acconcia

The paper identifies thioridazine as an anti-proliferative agent effective against ERα-expressing breast cancer cells resistant to tamoxifen.

bioRxiv · May 18, 2018Cancer Biology

A Functional Drug Re-Purposing Screening Identifies Carfilzomib As A Drug Preventing 17β-Estradiol: ERα Signaling And Cell Proliferation In Breast Cancer Cells

C. Busonero, S. Leone, C. Klemm, F. Acconcia

This study identifies carfilzomib as a drug that prevents 17β-estradiol:ERα signaling and inhibits cell proliferation in breast cancer cells, showing efficacy in tamoxifen-resistant models.

bioRxiv · May 3, 2017Cancer Biology