Author

A. E. Willis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

E. Villanueva· 2 shared K. S. Lilley· 2 shared M. Monti· 2 shared A. Craxton· 1 shared A. Dawson· 1 shared A. Herrero-Ruiz· 1 shared A. Naamati· 1 shared A. Nakas· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

E. Villanueva

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Interrogation of RNA-protein interaction dynamics in bacterial growth

M. Monti, R. Herman, K. Davey, C. S. Dawson, J. Ule, G. H. Thomas, A. E. Willis, K. S. Lilley, E. Villanueva

This study characterizes RNA-protein interaction dynamics in Escherichia coli across growth phases, identifying new RNA-binding proteins and their functions.

bioRxiv · Jul 3, 2023Microbiology

HSP70 binds to specific non-coding RNA and regulates human RNA Polymerase III

S. Leone, A. Srivastava, B. Hummel, L. Tittel, F. Aprile-Garcia, A. Herrero-Ruiz, P. Rawat, A. E. Willis, R. Sawarkar

This study identifies HSP70's interaction with non-coding RNA transcribed by RNA Polymerase III and shows its role in facilitating transcription of these RNAs.

bioRxiv · Apr 10, 2023Biochemistry

Metabolic reprogramming provides a novel approach to overcome resistance to BH3-mimetics in Malignant Pleural Mesothelioma

X.-M. Sun, G. J. Miles, A. Craxton, I. R. Powley, S. Galavotti, T. Chernova, A. Dawson, A. Nakas, A. E. Willis, K. Cain, M. MacFarlane

This study identifies metabolic reprogramming as a strategy to overcome resistance to BH3-mimetics in MPM by combining glycolytic inhibition with MCL-1 and BCL-2/BCL-XL targeting.

bioRxiv · Mar 31, 2023 · PreprintCell Biology

A system-wide quantitative map of RNA and protein subcellular localisation dynamics

E. Villanueva, T. Smith, M. Pizzinga, M. Elzek, R. M. L. Queiroz, R. F. Harvey, L. M. Breckels, O. M. Crook, M. Monti, V. Dezi, A. E. Willis, K. S. Lilley

The paper introduces LoRNA and a re-engineered LOPIT method to jointly map RNA and protein subcellular localisation, revealing dynamics during the unfolded protein response.

bioRxiv · Jan 24, 2022 · PreprintCell Biology

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

J. R. Knight, N. Vlahov, D. M. Gay, R. A. Ridgway, L. Faller, C. Proud, G. R. Mallucci, T. von der Haar, C. M. Smales, A. E. Willis, O. J. Sansom

The paper shows that Rpl24Bst mutation suppresses colorectal cancer by enhancing eEF2 phosphorylation through eEF2K, reducing protein synthesis and tumorigenesis.

bioRxiv · May 5, 2021Cancer Biology

A protease-activatable luminescent biosensor andreporter cell line for authentic SARS-CoV-2 infection

P. Pereyra Gerber, L. M. Duncan, E. J. Greenwood, S. Marelli, A. Naamati, A. Teixeira-Silva, T. W. Crozier, I. Gabaev, J. R. Zhan, T. E. Mulroney, E. C. Horner, R. Doffinger, A. E. Willis, J. E. Thanventhiran, A. V. Protasio, N. J. Matheson

This paper develops a luminescent biosensor and reporter cell line to quantify SARS-CoV-2 infection and neutralising antibodies efficiently.

bioRxiv · Mar 22, 2021Microbiology