F. Ferraro

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.

Evolution of the ribbon-like organization of the Golgi apparatus in animal cells

This study investigates the evolutionary origin of the Golgi ribbon in animal cells, identifies a molecular mechanism for its formation, and suggests its role in development.

The ribbon architecture of the Golgi apparatus is not restricted to vertebrates

This study shows that the Golgi ribbon structure, previously thought to be exclusive to vertebrates, is also present in sea urchin embryonic cells, indicating its evolutionary conservation in deuterostomes.

Immunosuppression and Outcomes in Acute Myeloid Leukemia

This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.

Structure modeling hints at a granular organization of the Vertebrate Golgi ribbon

The paper models Golgi ribbon structures to understand their impact on Weibel-Palade body size, finding that a model with differentially functioning monomer and dimer ministacks best fits experimental data.

Modulation of endothelial organelle size as an antithrombotic strategy

The paper identifies human-licenced drugs that reduce endothelial secretory granule size, offering potential antithrombotic compounds by modulating VWF adhesive activity.