MicrobiologybioRxiv
Inositol Phosphorlyceramide Synthase null Leishmania major (Δipcs-) are viable and virulent in animal infections where salvage of host sphingomyelin predominates
F. M. Kuhlmann, P. N. Key, S. M. Hickerson…·S. M. Beverley
This study shows that Leishmania major lacking inositol phosphorlyceramide synthase (IPCS) remains viable and virulent in mice, suggesting SM salvage compensates for IPC loss.
DOI 10.1016/j.jbc.2022.102522