Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic Leukemia
T. Carr, S. McGregor, S. Dias, M. Verykokakis, M. M. Le Beau, H.-H. Xue, E. T. Bartom, B. L. Kee
This study shows that the timing of Lef1 mutations in a murine T-ALL model affects its role as a tumor suppressor or oncogene, highlighting the importance of mutational order in leukemogenesis.
bioRxiv · Nov 8, 2021 · PreprintCancer Biology